Molecular formula: C 23 H 28 O 8 Molecular weight: Salvia divinorum is a 0. It can be easily recognised from its square-shaped and hollow stem and opposite pairs of ovate-lanceolate, jagged-edged leaves, which are usually velvety or hairy. The characteristic flower of the plant has a white corolla surrounded by a violet blue calyx. Salvia divinorum hardly ever sets seeds, and even when produced, they are rarely viable.
The propagation of the plant is thus exclusively vegetative and most of the Salvia divinorum plants now cultivated worldwide are clones of a few early Oaxaca collections. Dried and crushed leaves fortified with extracts from other leaves are dark green, brownish or even blackish green, due to concentrated pigments. Pure salvinorin A forms colourless crystals with a melting point of — o C.
Salvinorin A has a unique mode of action and pharmacology. Salvinorin A shows no significant binding to over 50 other psycho pharmacologically important receptors, transporter proteins and ion channels.
In humans, salvinorin A induces short-lived, profound hallucinations. Inhalation of doses equivalent to — micrograms of salvinorin A leads to loss of control over physical movements incapacitation ; uncontrollable laughter; vivid, colourful and often bizarre, dream- or film-like hallucinations. It has been reported that this can last for hours after the hallucinations have disappeared. Common after-effects include tiredness, dizziness and amnesia. Emergency reports have described lasting psychosis in vulnerable individuals.
Although preliminary experiments by Mowry et al. Because Salvia divinorum seeds are difficult to obtain, the plant is propagated from cuttings. Seedlings as well as dried leaves are readily available either from Internet suppliers or specialised shops in countries where no regulatory restrictions exist.
Home cultivation of plants is possible and instructions describing optimal growing conditions, the use of fertilisers and pest control chemicals are available on the Internet in several languages.
Salvinorin A is found in the resin secreted by special, hairy epidermal cells trichomes , which are especially abundant on the leaves. Preparations of one leaf fortified by extracts of 4 to 49 other leaves the respective products then labelled as 5X to 50X extracts are also available online and in specialised shops.
However, the actual salvinorin A concentration of Salvia divinorum products is generally unknown. Pure, crystalline salvinorin A does not appear to be offered on markets neither online or in smartshops but illustrated procedures for its isolation are available on the Internet.
Chemical total syntheses of salvinorin A have recently been completed but they are too complex to be used for the production of the substance. The half-gram dose was rarely detected by anyone. The 2. Effects from the dried Salvia leaves soaked and washed in water and then placed under the tongue were as follows. The actual technique is to chew the leaves every five minutes or so and return them to under the tongue.
The other half noticed nothing at all. Mind is clear and meditation is unusually easy with few distracting thoughts. This dose was only detected by anyone when they were trying to meditate. The effect made it easier tc oncentrate without thoughts If they, however, listened to music or did some activity they could not notice any effect at all. Effect is slight but it inhibits meditation for some. Generally people found that level too strong for meditation. The effect was enjoyable however So those are the casual results from the dose establishment phase of the study.
The next step will be the double blind study. May 1, These dosage levels are being established through a set of non-blind dose establishment sessions. The herb is administered sublingually in dried leaf form. This information can help your doctor provide more complete care and watch for complications that may be associated with use.
Keeping your doctor in the loop is especially important if you take prescription medications in addition to recreational drugs.
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Learn more about the potential benefits of English ivy as well as some possible downsides and how to use it. Health Conditions Discover Plan Connect. Salvia is smoked, normally in a bong or pipe but sometimes rolled with tobacco.
It can be chewed and orally absorbed. The smoke is normally held in for long periods to obtain the full effect. Smoking with a water pipe seems to produce the most immediate and extreme effects.
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